Yazar "Mansoor, Samman" için listeleme
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Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target
Ferreira, Juliana C.; Khrbtli, Abdul Rahman; Shetler, Cameron L.; Mansoor, Samman; Ali, Liaqat; Şensoy, Özge; Rabeh, Wael M. (American Society for Biochemistry and Molecular Biology Inc., 2021)Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 ... -
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
Mansoor, Samman; Kayık, Gülru; Durdağı, Serdar; Şensoy, Özge (Elsevier B.V., 2022)Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ... -
Utilization of biased G protein-coupled receptor signaling towards development of safer and personalized therapeutics
İlter, Metehan; Mansoor, Samman; Şensoy, Özge (MDPI, 2019)G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family. Discovery of beta-arrestin ...